GastroPlus
The premier PBPK/PBBM modeling and simulation platform for drug discovery and development.
Overview
GastroPlus® from Simulations Plus is the most cited PBPK modeling platform in scientific literature. It is used to simulate the pharmacokinetics of drugs in humans and animals, supporting decisions from early discovery through to regulatory submissions. It allows for the integration of physicochemical and in vitro data to predict in vivo performance, including drug-drug interactions and the effects of different formulations.
✨ Key Features
- Mechanistic PBPK and PBBM models
- Simulation of oral, IV, dermal, and other routes of administration
- Prediction of drug-drug interactions (DDIs)
- Virtual bioequivalence trials
- Population simulations
- Integration with ADMET Predictor for property prediction
- Used in regulatory submissions to FDA, EMA, and other agencies
🎯 Key Differentiators
- Most cited PBPK platform in the industry
- Strong regulatory acceptance
- User-friendly interface for a complex modeling tool
- Seamless integration with ADMET Predictor
Unique Value: Provides a highly validated and regulatory-accepted platform for PBPK modeling, enabling the reduction of clinical trials and acceleration of drug development.
🎯 Use Cases (5)
✅ Best For
- Widely used for regulatory submissions to major health authorities worldwide.
💡 Check With Vendor
Verify these considerations match your specific requirements:
- Primarily focused on pharmacokinetics, not a primary tool for initial hit identification.
🏆 Alternatives
Offers a more user-friendly interface and broader range of applications compared to some other PBPK modeling software.
💻 Platforms
✅ Offline Mode Available
🔌 Integrations
🛟 Support Options
- ✓ Email Support
- ✓ Phone Support
- ✓ Dedicated Support (Standard tier)
🔒 Compliance & Security
💰 Pricing
✓ 14-day free trial
Free tier: NA
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